Programme

The tentative programme run down of “9th Macau Symposium on Biomedical Sciences 2023” as follows:

This year’s symposium will be held in a format that combines online (via ZOOM) and in-person elements, in order to allow participants from around the world to participate in the event.

Participants who are unable to attend the symposium in person can join the meeting on ZOOM. ZOOM ID and password will be provided after registration.

15th Jun 2023 (THU) – AM 16th Jun 2023 (FRI) – AM 17th Jun 2023 (SAT) – AM
Venue: U-Hall Venue: U-Hall and Multi-function Hall Venue: U-Hall and Multi-function Hall
09:00 – 09:30 Opening Ceremony 09:30 – 12:30 09:30 – 12:30
Plenary Session ONE Concurrent Session 6 Concurrent Session 7 Concurrent Session 12 Concurrent Session 13
Coffee Break & Poster Session Coffee Break & Poster Session
Concurrent Session 8 Concurrent Session 9 Concurrent Session 14 Concurrent Session 15
12:30 – 14:00 Lunch & Poster Session 12:30 – 14:00 Lunch & Poster Session 12:30 – 14:00 Lunch & Poster Session
14th Jun 2023 (WED) – PM 15th Jun 2023 (THU) – PM 16th Jun 2023 (FRI) – PM 17th Jun 2023 (SAT) – PM
Venue: N21 – G013 Lecture Hall Venue: U-Hall and Multi-function Hall Venue: U-Hall and Multi-function Hall Venue: U-Hall
14:30 – 18:00 14:30 – 18:00 14:30 – 18:00 14:30 – 18:00
Session 1 Concurrent Session 2 Concurrent Session 3 Poster Session
Short talk for poster
Plenary Session TWO
 Seminar Series of Faculty of Health Sciences, University of Macau and College of Life Sciences, Zhejiang University on Biomedical Sciences Coffee Break & Poster Session Coffee Break & Poster Session
Concurrent Session 4 Concurrent Session 5 Concurrent Session 10 Concurrent Session 11 Best Poster Award
Closing Ceremony
Gala Dinner
14 Jun 2023 (Wed)
Venue: N21 – G013 Lecture Hall

Day 1 – PM
Session ONE
Exchange Session on Biomedical Sciences between Faculty of Health Sciences, University of Macau and
International School of Medicine, Zhejiang University
Session Chair(s)

Kai MIAO
Faculty of Health Sciences, University of Macau

Aifu LIN
International School of Medicine, Zhejiang University

14:30-14:35
Opening speech delivered by Prof. Chuxia DENG
Dean of the Faculty of Health Sciences of the University of Macau
14:35-14:40
Opening speech delivered by Dr. Wei LI
Deputy Secretary of the Communist Party Committee, The Fourth Affiliated Hospital, Zhejiang University School of Medicine &
International School of Medicine, Zhejiang University
14:40-15:00

Qiming SUN
International School of Medicine, Zhejiang University

Talk title: Cholesterol Metabolism Integrates ER Homeostasis and Innate Immunity

15:00-15:20

Dante NECULAI
International School of Medicine, Zhejiang University

Talk title: Excess Plasmalemmal Cholesterol Activates a Gαq/PLCβ3 Relay to Induce the Formation of E-SYT1-dependent ER-PM Contact Sites

15:20-15:40

Xin LI
International School of Medicine, Zhejiang University

Talk title: A Conserved Small RNA-based Genome Integrity Protection Mechanism

15:40-16:00

Bingbing WU
The Fourth Affiliated Hospital, Zhejiang University, School of Medicine

Talk title: Endometrial Development and Regeneration

16:00-16:30 Coffee Break
16:30-16:50

Edwin Chong Wing CHEUNG
Faculty of Health Sciences, University of Macau

Talk title: Nuclear Receptor Coregulator Function in Nuclear Hormone-Dependent Cancers

16:50-17:10

Gang LI
Faculty of Health Sciences, University of Macau

Talk title: Deciphering the Metabolic-epigenetic Crosstalk: AMPK’s Impact on TET2 and Transcriptional Regulation of Pax7

17:10-17:30

Fangyuan SHAO
The University of Macau

Talk title: Reversal of Broad Drug Resistance Through Increasing Mitochondrial OXPHOS to Induce Protein Neosynthesis

17:30-17:50

Guokai CHEN
Faculty of Health Sciences, University of Macau

Talk title: Metabolic Regulation on Pluripotency and Cell Fate Determination

18:30 (TBC)-20:00 Welcome Reception
Venue: 木偶葡國餐廳
15 Jun 2023 (Thu)
Venue: N2 – University Hall

Day 2 – AM
08:30-09:00 Registration/ Guest Reception
Opening Ceremony of the Ninth Macau Symposium on Biomedical Sciences
09:00-09:30
Welcome Remarks delivered by Prof. Yonghua SONG
Rector of the University of Macau
Address delivered by Mr. Kun Wai CHEANG
Acting President of the Administrative Committee of the Science and Technology Development Fund
Programme Introduction delivered by Prof. Chuxia DENG
Dean of the Faculty of Health Sciences of the University of Macau
Group Photo
Plenary Session ONE
Session Chair(s)

Chuxia DENG
Faculty of Health Sciences, University of Macau

09:30-10:10

Keynote Speaker: Mien-Chie HUNG
China Medical University

Talk title: Marker-guided Effective Therapy (Mget)

10:10-10:40

Weihong TAN
The Institute of Basic Medicine and Cancer, Chinese Academy of Sciences

Talk title: Molecular Mapping for Digitizing Single Cell

10:40-11:10

Fan ZHANG
Department of Chemistry, Fudan University

Talk title: Second Near-Infrared Window Fluorescent Probes for In Vivo Multiplexed Bioimaging

11:10-11:40 Coffee Break
11:40-12:10

Liang TONG
Department of Biological Sciences, Columbia University

Talk title: Molecular Insights into Human RNA 3’-end Processing and Relevance for Cancer Drug Discovery

12:10-12:40

Yehuda G. ASSARAF
Faculty of Biology, Technion – Israel Institute of Technology

Talk title: Lysosomal Biogenesis and Exocytosis as a Novel Target to Surmount Cancer Multidrug Resistance

12:40-14:30 Luncheon sponsored by 星創盈數碼科技工程一人有限公司 and Poster Session
Venue: N1 – Multi-function Hall
15th June 2023 (Thu)
Day 2 – PM
14:30-16:00 Session TWO
C. elegans Cell Biology: Membrane, Cytoskeleton and Organelle
Session THREE
Development of Smart Therapeutics and Drug Delivery Systems
Venue: N2 – University Hall
Venue: N1 – Multi-function Hall
Session Chair(s)

Hongjie ZHANG
Faculty of Health Sciences, University of Macau

Session Chair(s)

Ruibing WANG
Institute of Chinese Medical Sciences, University of Macau

Ying ZHENG
Institute of Chinese Medical Sciences, University of Macau

Guangshuo OU
School of Life Sciences, Tsinghua University

Talk title: Regulation of Intraflagellar Transport and Ciliopathies

Wei TAO (Online)
Innovation (Endowed Chair) | Brigham and Women’s Hospital;
Faculty of Medicine, Harvard University

Talk title: Nano-/Microscale Materials-enabled Drug Delivery Technologies

Xiaochen WANG
Institute of Biophysics, Chinese Academy of Science

Talk title: Maintenance of Lysosome Integrity and Function in C. Elegans

Jinyao LIU (Online)
Shanghai Jiaotong University

Talk title: Bacteria-based Therapeutics

Chonglin YANG
Yunnan University

Talk title: Understanding Metabolic Damage of Mitochondria

Feng QIAN
School of Pharmaceutical Sciences, Tsinghua University

Talk title: High Concentration Therapeutic Proteins: From Formulation Optimization to Protein Design

Anbing SHI
Huazhong University of Science and Technology

Talk title: How Cell Stabilizes Endosomal F-actin?

Zhen GU (Online)
College of Pharmaceutical Sciences, Zhejiang University

Talk title: Bioresponsive Drug Delivery

16:00-16:30 Coffee Break and Poster Session
Venue: N2 – University Hall
Coffee Break and Poster Session
Venue: N1 – Multi-function Hall
16:30-18:00 Session FOUR
Cancer Reserch and Therapy Development
Session FIVE
Biology of Aging
Venue: N2 – University Hall
Venue: N1 – Multi-function Hall
Session Chair(s)

Kathy Qian LUO
Faculty of Health Sciences, University of Macau

Session Chair(s)

Wakam CHANG
Faculty of Health Sciences, University of Macau

Session Co-Chair(s)

Garry WONG
Faculty of Health Sciences, University of Macau

Hanry YU
Mechanobiology Institute, National University of Singapore

Talk title: Contextual AI Approach of Classifying Earlier GI Tract Diseases

Zhongjun ZHOU
LKX Faculty of Medicine, The University of Hong Kong

Talk title: Disorganized Chromatin Hierarchy Drives Stem Cells Aging in Atypical Laminopathy-based Progeria Mandibuloacral dysplasia type A

Karl TSIM
Division of Life Science, The Hong Kong University of Science and Technology

Talk title: Phytochemicals Regulate Angiogenic Functions in Endothelial Cells by Binding to Vascular Endothelial Growth Factor (VEGF): Drug Development Targeting to Cancer Therapy

Yidong SHEN
Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

Talk title: The Trigger of the Germline Longevity

Peng CHEN
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University

Talk title: Imaging Guided Multimodal Cancer Therapy Based on Nano-Multizymes

Haiying LIU
School of Life Sciences, Sun Yat-Sen University

Talk title: Telomere Stability Regulation and Cellular Senescence

Godefridus J (Frits) PETERS
Amsterdam University Medical Centers, Vrije Universiteit Amsterdam

Talk title: Co-cultured Spheroids as Model Systems for Tumour Micro-environment and Drug Testing

Kathy Qian LUO
Faculty of Health Sciences, University of Macau

Talk title: Elucidating How Circulating Tumor Cells Resist Fluidic Shear Stress in Circulation and Acquire Stronger Metastatic Capacities

18:30-21:00 Gala Dinner
Venue: 港澳德興火鍋海鮮酒家
16 Jun 2023 (Fri)
Day 3 – AM
09:00-10:30 Session SIX
Drug Discovery and Biomaterials for Immune Regulation
Session SEVEN
Stem Cell, Gene & Cell Therapy
Venue: N2 – University Hall
Venue: N1 – Multi-function Hall
Session Chair(s)

Yunlu DAI
Faculty of Health Sciences, University of Macau

Joong Sup SHIM
Faculty of Health Sciences, University of Macau

Session Chair(s)

Guokai CHEN
Faculty of Health Sciences, University of Macau

Session Co-chair(s)

Ren-He XU
Faculty of Health Sciences, University of Macau

Yongjun DANG
Institute of Life Sciences, Chongqing Medical University

Talk title: Discovery of Small Molecules for
Tumour Immuno-Regulation

Ji DONG
Guangzhou National Laboratory

Talk title: A Single-nucleus Survey of Mammalian Hibernation for Liver Protection

Liang CHEN
Shenzhen Institute of Advanced Technology

Talk title: Proteostasis and Antitumour Immunity

Junjiu HUANG
School of Life Sciences, Sun Yat-Sen University

Talk title: Gene Editing Therapy of β-Thalassemia

Daishun LING
School of Chemistry and Chemical Engineering, Shanghai Jiaotong University

Talk title: Dynamic Nano-Assemblies-based Biomaterials and Drug Delivery Systems

Wanze CHEN
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Talk title: Live-seq Enables Temporal Transcriptomic Recording of Single Cells

Haijun YU
Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Talk title: Smart Nanomedicine for Cancer Immunotherapy

Xiaoyang ZHAO
Southern Medical University

Talk title: Understanding and Managing of Male Infertility Based on Mechanism Study

Chengtie WU (Online)
Shanghai Institute of Ceramics, Chinese Academy of Sciences

Talk title: 3D Printing of Biomimetic Biomaterials and Cells

10:30-11:00 Coffee Break and Poster Session
Venue: N2 – University Hall
Coffee Break and Poster Session
Venue: N1 – Multi-function Hall
11:00-12:30 Session EIGHT
Cell Death
Session NINE
G protein-Coupled Receptor: Structure, Signaling, and Diseases
Venue: N2 – University Hall
Venue: N1 – Multi-function Hall
Session Chair(s)

Hanming SHEN
Faculty of Health Sciences, University of Macau

Session Chair(s)

Leo Tsz On LEE
Faculty of Health Sciences, University of Macau

Session Co-Chair(s)

Yang DU
School of Medicine, Life and Health Sciences, The Chinese University of Hong Kong

Liming SUN
Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences

Talk title: Necroptosis on the Brake

Yang DU
School of Medicine, Life and Health Sciences, The Chinese University of Hong Kong

Talk title: Structure, Function and Drug Disovery of G Protein-coupled Receptor in Nervous System

Sudan HE
Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College

Talk title: The Role of RIPK1/RIPK3 in Inflammatory Responses Associated with GVHD

Sookja Kim CHUNG
Faculty of Medicine, Macau University of Science and Technology

Talk title: Exchange Proteins Activated by Cyclic AMP and Their Role in Diverse Function and Diseases

You-Sun KIM
Department of Biochemistry, Ajou University

Talk title: Necroptosis: Molecular Mechanisms and Disease Implications

Hsien-Da HUANG
School of Medicine, Life and Health Sciences, The Chinese University of Hong Kong

Talk title: Multi-omics in MicroRNA-related Biomarker and Drug Target Discovery

Francis Kaming CHAN
Zhejiang University Medical Center

Talk title: Immunogenic Cell Death: The Good, the Bad and the Ugly

Pei-Gen REN
Shenzhen Institute of Advanced Technology, China Academy of Sciences

Talk title: Development of Oral Polypeptide Drug Targeting GPRC6A for Nonalcoholic Steatohepatitis

Yung Hou WONG
Division of Life Science, The Hong Kong University of Science and Technology

Talk title: Preferential Binding of G Protein to the MT1 Protomer of the MT1/MT2 Heterodimeric Melatonin Receptor Complex

12:30-14:30 Luncheon sponsored by Thermo Fisher Scientific (Hong Kong) Limited and Poster Session
Venue: N1 – Multi-function Hall
16th Jun 2023 (Fri)
Day 3 – PM
14:30-16:30 Coffee Break and Poster Session
Venue: N1 – Multi-function Hall
16:30-18:00 Session TEN
Molecular Mechanism and Precise Diagnosis and Treatment of Cancer
Session ELEVEN
Spatial Omics Biology
Venue: N2 – University Hall
Venue: N1 – Multi-function Hall
Session Chair(s)

Kai MIAO
Faculty of Health Sciences, University of Macau

Session Chair(s)

Edwin CHEUNG
Faculty of Health Sciences, University of Macau

Peng WANG
Faculty of Health Sciences, University of Macau

Yuan LIU
Institute of Basic Medicine and Cancer, Chinese Academy of Sciences

Talk title: Nanoproteomics-based Biomarker Discovery and Cancer Diagnostics

Longqi LIU
BGI Research

Talk title: Large-field of View, High-Resolution Spatially Resolved Transcriptomics Using DNA Nanoball Patterned Array

Jiangjiang QIN
Institute of Basic Medicine and Cancer, Chinese Academy of Sciences

Talk title: Targeting UPS for Cancer Therapy: New Mechanisms and New Strategies

Xianting DING
School of Biomedical Engineering; Institute for Personalized Medicine, Shanghai Jiaotong University

Talk title: Single Cell Proteomic Analysis Techniques and Clinical Applications

Xiangsheng LIU
Institute of Basic Medicine and Cancer, Chinese Academy of Sciences

Talk title: Tumor Targeting Aptamer Drug Conjugate and Nano Drug Delivery System

Xiang ZHOU
School of Public Health, University of Michigan

Talk title: Statistical Methods for Spatial Transcriptomics

Ji JING
Institute of Basic Medicine and Cancer, Chinese Academy of Sciences

Talk title: Design Optogenetic Toolbox for Deep Understanding Intracellular Organelles Communications and Remote Control of Programmed Cell Death

17 Jun 2023 (Sat)
Day 4 – AM
09:00-10:30 Session TWELVE
TCM and Natural Product-based Drug Discovery
Session THIRTEEN
Targeting Gut Microbiota and Metabolism for Cancer Immunomodulation
Venue: N2 – University Hall
Venue: N1 – Multi-function Hall
Session Chair(s)

Xiuping CHEN
Institute of Chinese Medical Sciences, University of Macau

Ying WANG
Institute of Chinese Medical Sciences, University of Macau

Session Chair(s)

Elaine LEUNG
Faculty of Health Sciences, University of Macau

Hong PENG (Online)
Yale University

Talk title: Roles of University Technology Transfer in Biomedical Business

Xiang ZHANG
Faculty of Medicine, The Chinese University of Hong Kong

Talk title: Gut Microbiota, Metabolites and Fatty Liver Diseases

Jinhua WANG (Online)
The Institute of Materia Medica, Chinese Academy of Medical Sciences

Talk title: The Study on Anti-Glioblastoma Effect and Its Mechanism of Sinomenine Ester Derivative

Yuting YANG on behalf of Hong WEI
The First Affiliated Hospital, Sun Yat-Sen University

Talk title: Humanized Germ-free Animal Models and Their Roles in the Study of Microbiome Related Tumor Genesis and Development and Immunotherapy

Hubing SHI
West China Hospital, Sichuan University

Talk title: Immune Checkpoint HLA-E:CD94-NKG2A Mediates Evasion of Circulating Tumor Cells from NK Cell Surveillance

Di LIU
Wuhan Institute of Virology, Chinese Academy of Sciences

Talk title: Intestinal Microbiome and Disease Health

Liwu FU
Cancer Center, Sun Yat-Sen University

Talk title: Progress in the Personalization of Tumour Chemotherapeutic Drug

Carmen Chak-Lui WONG
School of Clinical Medicine, The University of Hong Kong

Talk title: Precision Medicine and the Mechanistic Basis of Combination Treatments for Liver Cancer

Hoi Leong Xavier WONG
School of Chinese Medicine, Hong Kong Baptist University

Talk Title: Therapeutic Targets of Metabolic Disorders- What’s New?

10:30-11:00 Coffee Break and Poster Session
Venue: N2 – University Hall
Coffee Break and Poster Session
Venue: N1 – Multi-function Hall
11:00-12:30 Session FOURTEEN
Molecular Probes and Biosensors
Session FIFTEEN
Neuroscience, Aging and Degenerative Diseases
Venue: N2 – University Hall
Venue: N1 – Multi-function Hall
Session Chair(s)

Xuanjun ZHANG
Faculty of Health Sciences, University of Macau

Xiaoqiang CHEN
College of Chemical Engineering, Nanjing Tech University

Session Chair(s)

Wenhua ZHENG
Faculty of Health Sciences, University of Macau

Session Co-Chair(s)

Jiangang SHEN
School of Chinese Medicine, The University of Hong Kong

Zhizeng GAO
School of Marine Sciences, Sun Yat-Sen University

Talk title: Development of Fluorescent Polarization-based High Throughput Screening Assays

Qing WANG
Zhujiang Hospital of Southern Medical University

Talk title: Neurovascular Unit Roles in Neurodegeneration

Zonghai SHENG
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

Talk title: Recent Advances in ICG Near-Infrared Fluorescence Molecular Imaging in the Second Biowindow

Xintong LIU
Institute of Cerebrovascular Diseases, Guangdong No. 2 General Hospital

Talk title: Research Progress in Prehospital Neuroprotection of Acute Stroke.

Xiaoqiang CHEN
College of Chemical Engineering, Nanjing Tech University

Talk title: Functional Dyes for Imaging and Detection Applications

Xifei YANG
Shenzhen Center for Disease Control and Prevention

Talk title: Adiponectin Deficiency Accelerates Brain Aging via Mitochondria-associated Neuroinflammation

Peng GUO
Institute of Basic Medicine and Cancer, Chinese Academy of Sciences

Talk title: Spatiotemporal Visualization of Bystander Activity of Antibody Drug Conjugates for Enhancing Solid Tumour Penetration

Haiwei HUANG
The First Affiliated Hospital, Sun Yat-Sen University

Talk title: Effect of Vestibular Dysfunction on Cognition

Jiangang SHEN
School of Chinese Medicine, The University of Hong Kong

Talk title: Hypochlorous Acid Derived from Microglial Myeloperoxidase Mediates High-mobility Group Box 1 Release from Neurons to Amplify Brain Damage in Cerebral Ischemia-reperfusion Injury

12:30-14:30 Luncheon sponsored by LingBio Biotechnology Macau Company Ltd and Poster Session
Venue: N1 – Multi-function Hall
17th Jun 2023 (Sat)
Venue: N2 – University Hall

Day 4 – PM
Plenary Session TWO
Session Chair(s)

Chuxia DENG
Faculty of Health Sciences, University of Macau

14:30-15:10

Keynote Speaker: Dennis LO
Faculty of Medicine, The Chinese University of Hong Kong

Talk title: Creating Paradigms Shift in Molecular Diagnostics

15:10-15:40

Alexander HOFFMANN
Microbiology and Immunology; The Institute for Quantitative and Computational Biosciences, University of California

Talk title: A Temporal Signaling Code to Specify Immune Responses

15:40-16:10

Gourisankar GHOSH
Department of Chemistry and Biochemistry, University of California San Diego

Talk title: Diverse Nuclear Factors are Enablers of NF-kB’s Transcriptional Activity

16:10-16:40 Coffee Break
16:40-17:10

Hong ZHANG
Institute of Biophysics, Chinese Academy of Sciences

Talk title: Liquid–liquid Phase Separation in Autophagy

17:10-17:40

Richard J. YOULE
National Institute of Neurological Disorders and Stroke, National Institutes of Health

Talk title: Mitochondria Quality Control and Parkinson’s Disease

17:40-18:10 Short talk for poster
18:10-18:30 Best Poster Awards
Closing Ceremony of the Ninth Macau Symposium on Biomedical Sciences
Closing Speech by Prof. Renhe XU
Associate Dean of the Faculty of Health Sciences of the University of Macau